? Why are peptide bonds uncommon or rare in proteins
Two configurations are possible for a planar peptide bond. In
the trans configuration, the two a-carbon atoms are on opposite sides of the
peptide bond. In the cis configuration, these groups are on the same side of
the peptide bond. Almost all peptide bonds in proteins are trans. This
preference for trans over cis can be explained by the fact that steric clashes between groups attached to the a-carbon
atoms hinder the formation of the cis form but do not arise in the trans
configuration (Figure 2.20).
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